Naltrexone is an FDA-approved medication traditionally used at higher doses to treat opioid and alcohol dependence. At much lower doses it may have different pharmacological effects, and research has explored its potential effects on immune and inflammatory pathways.
Because commercially available naltrexone is generally made only in higher strengths, compounding pharmacies prepare patient-specific low-dose formulations from a provider's prescription. EpitomeRx works with providers to develop individualized LDN formulations for each patient's treatment plan.
Conditions where LDN may be considered
Healthcare providers may prescribe low dose naltrexone within individualized treatment plans for conditions including:
- Chronic pain conditions such as fibromyalgia and CRPS
- Inflammatory bowel disease (Crohn's disease, ulcerative colitis)
- Multiple sclerosis
- ME/chronic fatigue syndrome and post-COVID conditions
- Inflammatory skin conditions such as psoriasis, Hailey-Hailey disease and lichen planopilaris
- Vulvodynia and interstitial cystitis
These uses are off-label. Your provider decides whether LDN is appropriate for you. See the evidence behind each condition.
Learn more: The LDN Research Trust, a registered charity, offers patient guides and research summaries. EpitomeRx is not affiliated with the LDN Research Trust. ldnresearchtrust.org ↗
Compounded medications require a prescription from a licensed healthcare provider and are not FDA approved. This page is educational and is not medical advice.