What is Low Dose Naltrexone?
Low dose naltrexone (LDN) is naltrexone hydrochloride prepared at much lower strengths than the 50 mg manufactured tablet, typically a few milligrams. Research has explored its effects on immune and inflammatory pathways, and providers may include it in individualized plans for certain chronic conditions.
Every use of naltrexone at these doses is off-label. The decision to prescribe LDN, and at what dose, belongs to your healthcare provider.
Why does it have to be compounded?
Naltrexone tablets are manufactured at 50 mg. Low strengths cannot be made accurately by splitting tablets at home, so a compounding pharmacy prepares capsules or a 1 mg/mL oral suspension at the prescribed strength.
Areas of clinical interest
- Chronic pain conditions such as fibromyalgia and CRPS
- Inflammatory bowel disease (Crohn's disease, ulcerative colitis)
- Multiple sclerosis
- ME/chronic fatigue syndrome and post-COVID conditions
- Inflammatory skin conditions such as psoriasis, Hailey-Hailey disease and lichen planopilaris
- Vulvodynia and interstitial cystitis
These are areas of ongoing research, not approved uses. Talk with your provider about whether LDN fits your care.
Learn more: The LDN Research Trust, a registered charity, offers patient guides and research summaries. EpitomeRx is not affiliated with the LDN Research Trust. ldnresearchtrust.org ↗
Safety information
Compounded LDN is not FDA approved. Naltrexone blocks opioid medications; tell every provider you see that you take it. Do not take LDN with opioid medications unless your provider directs you to.
This list isn't all-inclusive. Your provider can prescribe other strengths, combinations or dosage forms. Call us at 626.631.6150 and we'll work with you and your provider to find an option that fits.
Common questions
Is LDN a controlled substance?
No. Naltrexone is not a controlled substance.
Can I split a 50 mg tablet instead?
No. Splitting cannot deliver an accurate low dose. Ask your provider to send a prescription for compounded LDN.
When should I take LDN?
Follow your label. Many providers prescribe it at bedtime; some prescribe morning dosing.