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Low dose naltrexone: why the dose has to be compounded

Naltrexone is manufactured as a 50 mg tablet. Here's why low-dose prescriptions come from a compounding pharmacy, and what to expect when you fill one.

Naltrexone has been FDA approved for decades at 50 mg for alcohol and opioid dependence. In recent years, providers have taken interest in using it at a small fraction of that dose, usually a few milligrams, as part of individualized plans for certain chronic conditions. That practice is known as low dose naltrexone, or LDN.

There's no manufactured low-dose tablet

Naltrexone tablets are manufactured at 50 mg. A low-dose prescription therefore can't be filled from a stock bottle. It has to be prepared by a compounding pharmacy at the exact strength the provider writes.

Some people try to split or dissolve 50 mg tablets at home. We don't recommend it: a typical low dose is a small fraction of the tablet, and home methods can't measure that accurately.

The forms we prepare

  • Capsules for a steady, simple daily dose
  • 1 mg/mL oral suspension when your provider wants to increase the dose in small steps
  • Allergen-conscious capsules for patients sensitive to common fillers
  • Topical cream when prescribed for skin conditions

What to expect

Your provider decides whether LDN fits your care, the starting dose and how to adjust it. Once we receive the prescription, we'll call to confirm the details and pricing, prepare your medication, and ship it anywhere in California. Local pickup in Arcadia is available by calling ahead.

LDN is used off-label, and compounded medications are not FDA approved. Always talk with your healthcare provider about your treatment, and tell every provider you see that you take naltrexone.

Learn more about LDN at EpitomeRx

This article is educational and is not medical advice. Talk with your healthcare provider about your treatment.

Have questions about personalized compounding?

Call our pharmacist to talk through your prescription, pricing and options.